4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol

Base Information

• Chemical Name: 4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol
• CAS No.: 932393-67-4
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.338
• Mol file: 932393-67-4.mol

Synonyms:4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol

Chemical Property of 4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol

There total 1 articles about 4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1-ethenylcyclohexene (931-49-7) + 2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde (32233-44-6) → 4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol (932393-67-4)

Guidance literature:

1-ethenylcyclohexene; With n-butyllithium; In tetrahydrofuran; at -50 - 20 ℃;

2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde; In tetrahydrofuran;

DOI:10.1002/anie.200604006

Reference yield: 46.0%

4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol (932393-67-4) → (4S)-4-(4-cyclohex-1-enylbuta-2,3-dienyl)-2,2-dimethyl[1,3]dioxolane

Guidance literature:

With 2-nitrobenzenesulfonyl hydrazide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at -15 - 23 ℃;

DOI:10.1002/anie.200604006

Reference yield:

methyl chloroformate (79-22-1) + 4-Cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-yn-2-ol (932393-67-4) → Carbonic acid 3-cyclohex-1-enyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-prop-2-ynyl ester methyl ester

Guidance literature:

With ethylmagnesium bromide; Multistep reaction;

upstream raw materials:

1-ethenylcyclohexene

2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde