(3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate

Base Information

Chemical Name:(3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate
CAS No.:1392104-14-1
Molecular Formula:C₃₈H₅₈O₆Si₂
Molecular Weight:667.046
Hs Code.:

Synonyms:(3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate

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Chemical Property of (3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate

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Technology Process of (3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate

There total 1 articles about (3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 108-05-4,9003-20-7
vinyl acetate

: 11(S)-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-⁽³⁾-ol

: 1392104-14-1
(3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate

Guidance literature:: With Novozyme 435 lipase acrylic resin; In hexane; at 50 ℃; for 1h; Microwave irradiation;
DOI:10.1039/c2ob06802h

Reference yield: 97.0%

: 1392104-14-1
(3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate

: 1392104-11-8
(3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-ol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 0.333333h;
DOI:10.1039/c2ob06802h

Reference yield:

: 1392104-14-1
(3S,11S)-11-(tert-butyldimethylsilyloxy)-12-(tert-butyldiphenylsilyloxy)-7-(1,3-dioxolan-2-yl)dodec-1-yn-3-yl acetate

: 1392104-37-8
14-(4-(8-((tert-butyldiphenylsilyloxy)methyl)-1,7-dioxaspiro[5.5]undecan-2-yl)-1H-1,2,3-triazol-1-yl)tetradecane-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol / 0.33 h / 20 °C

2: camphor-10-sulfonic acid / ethanol; water / 3 h / 20 °C

3: triethylphosphite copper(I) iodide complex / toluene / Inert atmosphere; Reflux

With triethylphosphite copper(I) iodide complex; camphor-10-sulfonic acid; potassium carbonate; In methanol; ethanol; water; toluene;
DOI:10.1039/c2ob06802h