methyl 2-(4-chlorophenyl)-2-propylbutanoate

Base Information

• Chemical Name: methyl 2-(4-chlorophenyl)-2-propylbutanoate
• CAS No.: 215808-00-7
• Molecular Formula: C₁₄H₁₉ClO₂
• Molecular Weight: 254.757
• Mol file: 215808-00-7.mol

Synonyms:methyl 2-(4-chlorophenyl)-2-propylbutanoate

Chemical Property of methyl 2-(4-chlorophenyl)-2-propylbutanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 2-(4-chlorophenyl)-2-propylbutanoate

There total 1 articles about methyl 2-(4-chlorophenyl)-2-propylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(4-amino-phenyl)-ethyl]-pentanoic acid methyl ester; hydrochloride → methyl 2-(4-chlorophenyl)-2-propylbutanoate (215808-00-7)

Guidance literature:

With urea; copper(l) chloride; sodium nitrite; Yield given; Multistep reaction; 1.) water, 0-5 deg C, 1 h, 2.) water, 0 -> 60 deg C;

DOI:10.1021/jo981279t

Reference yield: 67.0%

methyl 2-(4-chlorophenyl)-2-propylbutanoate (215808-00-7) → 4-(4-chlorophenyl)-2-propylbutanoic acid

Guidance literature:

With sodium hydroxide; In methanol; water; for 6h; Heating;

DOI:10.1021/jo981279t

Reference yield:

methyl 2-(4-chlorophenyl)-2-propylbutanoate (215808-00-7) → 2-diazo-6-(4-chlorophenyl)-4-propyl-3-hexanone (215808-05-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / NaOH / methanol; H₂O / 6 h / Heating

2: oxalyl chloride / hexane / 1.5 h / Heating

3: 440 mg / hexane; diethyl ether / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

With sodium hydroxide; oxalyl dichloride; In methanol; diethyl ether; hexane; water;

DOI:10.1021/jo981279t

Downstream raw materials:

2-diazo-6-(4-chlorophenyl)-4-propyl-3-hexanone