7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1334718-53-4
Molecular Formula:C₂₅H₁₈ClF₃N₄O₃
Molecular Weight:514.891
Hs Code.:

Synonyms:7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of 7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of 7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 4 articles about 7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334721-52-6
7-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxylic acid

: C₁₅H₁₁F₃N₂O₂

: 1334718-53-4
7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.05.021

Reference yield:

: 4949-44-4
ethyl propanoylacetate

: 1334718-53-4
7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; ammonium acetate / diethyl ether / 6 h / 20 °C / Inert atmosphere

2: ethanol / Reflux; Inert atmosphere

3: lithium hydroxide / ethanol; water / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere

With N-Bromosuccinimide; ammonium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.05.021

Reference yield:

: 87943-99-5
ethyl 2-bromo-3-oxopentanoate

: 1334718-53-4
7-chloro-2-ethyl-N-((2-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-5-yl)methyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / Reflux; Inert atmosphere

2: lithium hydroxide / ethanol; water / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.05.021