2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole

Base Information

Chemical Name:2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole
CAS No.:1422200-36-9
Molecular Formula:C₂₂H₁₆F₄N₂O₂
Molecular Weight:416.375
Hs Code.:

Synonyms:2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole

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Technology Process of 2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole

There total 3 articles about 2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: lithium 2-methylpropan-2-olate

: 6-fluorobenzo[d]oxazole

: 541549-19-3
2-(pentafluorophenyl)-pyridine

: 1422200-36-9
2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); o-phenylenebis(diphenylphosphine); In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; Inert atmosphere;
DOI:10.1021/ol303567t

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1422200-36-9
2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1,10-Phenanthroline; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 120 °C

2: dichloro bis(acetonitrile) palladium(II); o-phenylenebis(diphenylphosphine) / 5,5-dimethyl-1,3-cyclohexadiene / 130 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; o-phenylenebis(diphenylphosphine); In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1021/ol303567t

Reference yield:

: 363-72-4
Pentafluorobenzene

: 1422200-36-9
2-(2-tert-butoxy-3,4,5-trifluoro-6-(pyridin-2-yl)phenyl)-6-fluorobenzoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1,10-Phenanthroline; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 120 °C

2: dichloro bis(acetonitrile) palladium(II); o-phenylenebis(diphenylphosphine) / 5,5-dimethyl-1,3-cyclohexadiene / 130 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; o-phenylenebis(diphenylphosphine); In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1021/ol303567t