Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate

Base Information

• Chemical Name: Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate
• CAS No.: 225242-24-0
• Molecular Formula: C₁₈H₁₆Br₂O₅
• Molecular Weight: 472.13
• Mol file: 225242-24-0.mol

Synonyms:Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate

Chemical Property of Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate

There total 1 articles about Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Dimethyl 5-hydroxyisophthalate (13036-02-7) + 1-methyl-4-(bromomethylene)-2,5-dibromobenzene (188403-43-2) → Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate (225242-24-0)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1002/1521-3765(20000901)6:17<3235::AID-CHEM3235>3.0.CO;2-4

Reference yield: 88.0%

Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate (225242-24-0) → 5-(2,5-Dibromo-4-methylbenzyloxy)-1,3-benzenedimethanol (225242-28-4)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; for 6h; Heating;

DOI:10.1002/1521-3765(20000901)6:17<3235::AID-CHEM3235>3.0.CO;2-4

Reference yield:

Dimethyl 5-(2,5-dibromo-4-methylbenzyloxy)-1,3-benzenedicarboxylate (225242-24-0) → 2,5-Dibromo-4-methyl-1-[3,5-bis(bromomethyl)phenoxymethyl]benzene (220486-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / LiBH₄ / tetrahydrofuran / 6 h / Heating

2: 83 percent / CBr₄; PPh₃ / tetrahydrofuran / 1 h / 0 °C

With lithium borohydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; 1: Reduction / 2: Substitution;

DOI:10.1002/1521-3765(20000901)6:17<3235::AID-CHEM3235>3.0.CO;2-4

upstream raw materials:

Dimethyl 5-hydroxyisophthalate

1-methyl-4-(bromomethylene)-2,5-dibromobenzene

Downstream raw materials:

5-(2,5-Dibromo-4-methylbenzyloxy)-1,3-benzenedimethanol

2,5-Dibromo-4-methyl-1-[3,5-bis(bromomethyl)phenoxymethyl]benzene