(S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

Base Information

Chemical Name:(S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester
CAS No.:175659-66-2
Molecular Formula:C₂₁H₂₉N₃O₅
Molecular Weight:403.478
Hs Code.:

Synonyms:(S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

Suppliers and Price of (S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

There total 7 articles about (S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 175659-65-1
(S)-2-{[(3S,6S,8aS)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl]-amino}-4-methyl-pentanoic acid benzyl ester

: 175659-66-2
(S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

Guidance literature:: With potassium fluoride; 18-crown-6 ether; In N,N-dimethyl-formamide; other reagent: piperidine;
DOI:10.1016/0960-894X(96)00055-8

Reference yield:

: 141362-49-4
phenylmethyl (S)-2-amino-5-hexenoate

: 175659-66-2
(S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate

2: 1.) ozone, 2.) triphenylphosphine / 1.) CH₂Cl₂, -78 deg C

3: 1.) trifluoroacetic acid, 2.) trifluoroacetic acid / 1.) CH₂Cl₂, reflux, 1 h, 2.) 3 d

4: 97 percent / H₂ / Pd/C / ethanol

5: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate

6: 96 percent / KF, 18-crown-6 / dimethylformamide / other reagent: piperidine

With potassium fluoride; 18-crown-6 ether; hydrogen; ozone; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00055-8

Reference yield:

: 175659-62-8
(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-propionylamino]-hex-5-enoic acid benzyl ester

: 175659-66-2
(S)-2-[((3S,6S,8aS)-3-Amino-4-oxo-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) ozone, 2.) triphenylphosphine / 1.) CH₂Cl₂, -78 deg C

2: 1.) trifluoroacetic acid, 2.) trifluoroacetic acid / 1.) CH₂Cl₂, reflux, 1 h, 2.) 3 d

3: 97 percent / H₂ / Pd/C / ethanol

4: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate

5: 96 percent / KF, 18-crown-6 / dimethylformamide / other reagent: piperidine

With potassium fluoride; 18-crown-6 ether; hydrogen; ozone; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00055-8