methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Base Information

Chemical Name:methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate
CAS No.:313736-28-6
Molecular Formula:C₂₈H₃₇NO₄
Molecular Weight:451.606
Hs Code.:

Synonyms:methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

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Chemical Property of methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

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Technology Process of methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

There total 16 articles about methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 279262-28-1
{4-[2-(butoxy)ethoxy]phenyl}boronic acid

: 313736-13-9
methyl 7-bromo-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

: 313736-28-6
methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; Heating;
DOI:10.1248/cpb.52.577

Reference yield:

: 4-(2-butoxyethoxy)phenyl borate

: 313736-13-9
methyl 7-bromo-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

: 313736-28-6
methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Guidance literature:: 4-(2-butoxyethoxy)phenyl borate; methyl 7-bromo-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate; With potassium carbonate; In ethanol; water; toluene; for 0.5h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 14h; Heating / reflux;

Reference yield:

: 313724-44-6
methyl 7-bromo-2,3-dihydro-1H-benzo[b]azepine-4-carboxylate

: 313736-28-6
methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / triacetoxyborohydride / 1,2-dichloro-ethane / 12 h / 20 °C

2: 62 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene; ethanol / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium triacetoxyborohydride; potassium carbonate; In ethanol; 1,2-dichloro-ethane; toluene; 2: Suzuki coupling;
DOI:10.1248/cpb.52.577