3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Base Information

Chemical Name:3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide
CAS No.:871657-54-4
Molecular Formula:C₁₄H₁₇N₃O₄
Molecular Weight:291.307
Hs Code.:

Synonyms:3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Chemical Property of 3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Technology Process of 3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

There total 7 articles about 3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871657-55-5
3-hydroxy-5-[(1R)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

: 871657-54-4
3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: 3-hydroxy-5-[(1R)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide; With trimethylsilyl iodide; In acetonitrile; for 24h;

With methanol; for 0.5h;

Reference yield:

: 871657-58-8
methyl 3-{[(1R)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoate

: 871657-54-4
3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 20 h / 20 °C

1.2: pH 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h

3.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 h / 20 °C

5.1: trimethylsilyl iodide / acetonitrile / 24 h

5.2: 0.5 h

With lithium hydroxide; oxalyl dichloride; trimethylsilyl iodide; water; hydrogen; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 871657-57-7
3-(benzyloxy)-5-[(1R)-2-methoxy-1-methylethoxy]benzoic acid

: 871657-54-4
3-hydroxy-5-[(1R)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h

2.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 h / 20 °C

4.1: trimethylsilyl iodide / acetonitrile / 24 h

4.2: 0.5 h

With oxalyl dichloride; trimethylsilyl iodide; hydrogen; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;