N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide

Base Information

Chemical Name:N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide
CAS No.:1350454-85-1
Molecular Formula:C₃₀H₂₈F₃N₇O₃S
Molecular Weight:623.659
Hs Code.:

Synonyms:N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide

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Chemical Property of N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide

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Technology Process of N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide

There total 6 articles about N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 6-(3-methoxyphenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 1360816-10-9
C₁₄H₁₈F₃N₃O₂

: 1350454-85-1
N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 1350454-85-1
N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 16 h / Reflux

2: palladium diacetate; caesium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 12 h / 80 °C

3: Oxone / methanol; water / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With Oxone; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 815596-13-5
6-(3-Methoxyphenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 1350454-85-1
N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)-4-morpholinobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / methanol; water / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With Oxone; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.024