(4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate

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Chemical Name:(4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate
CAS No.:1221264-23-8
Molecular Formula:C₃₂H₄₂N₂O₇
Molecular Weight:566.695
Hs Code.:

Synonyms:(4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate

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Chemical Property of (4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate

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Technology Process of (4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate

There total 7 articles about (4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 95798-31-5
(4S)-3-(3-phenylpropionyl)-4-(2-propyl)oxazolidin-2-one

: 250122-39-5
tert-butyl (2R,4R)-4-(benzyloxy)-2-formylpyrrolidine-1-carboxylate

: 1221264-23-8
(4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate

Guidance literature:: (4S)-3-(3-phenylpropionyl)-4-(2-propyl)oxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

tert-butyl (2R,4R)-4-(benzyloxy)-2-formylpyrrolidine-1-carboxylate; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With dihydrogen peroxide; In dichloromethane; water; at 0 ℃; for 1h; Aqueous phosphate buffer;

Reference yield:

: 114676-59-4
(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride

: 1221264-23-8
(4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / water; acetone

2.1: silver(l) oxide / N,N-dimethyl-formamide / 36 h / 0 °C

3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

3.2: 0 °C / pH 4

4.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 0.5 h / 0 - 20 °C

5.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

5.3: 1 h / 0 °C / Aqueous phosphate buffer

With dmap; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 114676-69-6
(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 1221264-23-8
(4R)-tert-butyl 2-((1S,2S)-2-benzyl-1-hydroxy-3-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-3-oxopropyl)-4-(benzyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver(l) oxide / N,N-dimethyl-formamide / 36 h / 0 °C

2.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.2: 0 °C / pH 4

3.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 0.5 h / 0 - 20 °C

4.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

4.3: 1 h / 0 °C / Aqueous phosphate buffer

With lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;