1-BOC-4-(2,4-DIFLUOROPHENYL)-4-HYDROXYPIPERIDINE

Base Information

Chemical Name:1-BOC-4-(2,4-DIFLUOROPHENYL)-4-HYDROXYPIPERIDINE
CAS No.:941711-19-9
Molecular Formula:C₁₆H₂₁F₂NO₃
Molecular Weight:313.344
Hs Code.:
Mol file:941711-19-9.mol

Synonyms:4-(2,4-difluoro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 1-BOC-4-(2,4-DIFLUOROPHENYL)-4-HYDROXYPIPERIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
1-Boc-4-(2,4-difluorophenyl)-4-piperidinol 97%
5g
$ 440.00

ACHEMBLOCK
1-Boc-4-(2,4-difluorophenyl)-4-piperidinol 95%
10G
$ 810.00

ACHEMBLOCK
1-Boc-4-(2,4-difluorophenyl)-4-piperidinol 95%
1G
$ 180.00

Total 2 raw suppliers

Chemical Property of 1-BOC-4-(2,4-DIFLUOROPHENYL)-4-HYDROXYPIPERIDINE

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

1-Boc-4-(2,4-difluorophenyl)-4-piperidinol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(2,4-DIFLUOROPHENYL)-4-HYDROXYPIPERIDINE

There total 3 articles about 1-BOC-4-(2,4-DIFLUOROPHENYL)-4-HYDROXYPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 941711-19-9
4-(2,4-difluoro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 2,4-difluorobromobenzene; With n-hexyllithium; In diethyl ether; hexane; at -78 ℃; for 1h;

N-tert-butyloxycarbonylpiperidin-4-one; In diethyl ether; hexane; at -78 - 20 ℃; for 0.5h;

Reference yield:

: 2,4-difluorophenylmagnesium chloride

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 941711-19-9
4-(2,4-difluoro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 2,4-difluorophenylmagnesium chloride; N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran; at -78 ℃;

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 941711-19-9
4-(2,4-difluoro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C

2.1: tetrahydrofuran / -78 - 20 °C

2.2: -78 °C

In tetrahydrofuran;