L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N⁵-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester

Base Information

• Chemical Name: L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N⁵-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester
• CAS No.: 503173-71-5
• Molecular Formula: C₄₄H₆₅N₇O₁₂S
• Molecular Weight: 916.106

Synonyms:L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N⁵-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester

Chemical Property of L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N⁵-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester

Chemical Property:

Purity/Quality:

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Technology Process of L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N⁵-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester

There total 5 articles about L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N⁵-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-aspartic acid di-tert-butyl ester (13795-73-8) → L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N5-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester (503173-71-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / DIPEA / dimethylformamide / 4 h / 0 - 20 °C

2: H₂ / 10percent Pd/C / ethanol

3: DPPA, DIPEA / dimethylformamide / 10 h / 0 °C

With diphenyl-phosphinic acid; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja972467o

Reference yield:

(S)-di-tert-butyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)succinate (113170-90-4) → L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N5-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester (503173-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol

2: DPPA, DIPEA / dimethylformamide / 10 h / 0 °C

With diphenyl-phosphinic acid; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja972467o

Reference yield:

(S)-di-tert-butyl 2-(2-aminoacetamido)succinate (92050-81-2) + N-[(phenylmethoxy)carbonyl]glycyl-N5-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithyl acid → L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N5-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester (503173-71-5)

Guidance literature:

With diphenyl-phosphinic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 10h; Yield given;

DOI:10.1021/ja972467o

upstream raw materials:

(S)-di-tert-butyl 2-(2-aminoacetamido)succinate

Cbz-Gly-ONSuc

L-aspartic acid di-tert-butyl ester

N^G-2,2,5,7,8-pentamethylchroman-6-sulfonyl-L-arginine

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