2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

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Chemical Name:2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester
CAS No.:217792-91-1
Molecular Formula:C₄₂H₆₃N₆O₁₁PS₂
Molecular Weight:923.102
Hs Code.:

2,2-dimethyl-thiopropionic acid <i>S</i>-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

Synonyms:2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

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Chemical Property of 2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

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Technology Process of 2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

There total 7 articles about 2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 217792-96-6
C₅₇H₇₃N₆O₁₃PS₂

: 217792-91-1
2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 0.25h;
DOI:10.1021/jo980437d

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 217792-91-1
2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

2: trifluoroacetic acid / CH₂Cl₂ / 0.5 h

3: 300 mg / N,N-diisopropyl-N-ethylamine, benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 2 h / Ambient temperature

4: 82 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 0.25 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo980437d

Reference yield:

: 112883-29-1,92954-90-0
N-Fmoc-Tyr-OH

: 217792-91-1
2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

2: 300 mg / N,N-diisopropyl-N-ethylamine, benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 2 h / Ambient temperature

3: 82 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 0.25 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo980437d