2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine

Base Information

Chemical Name:2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine
CAS No.:104404-90-2
Molecular Formula:C₁₉H₂₄ClN₅O₂
Molecular Weight:389.885
Hs Code.:

Synonyms:2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine

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Chemical Property of 2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine

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Technology Process of 2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine

There total 4 articles about 2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 104404-90-2
2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 0.1N HCl, NaOAc / dioxane; H₂O / 72 h / Ambient temperature

2: 81 percent / NH₄OAc / acetic acid / 24 h / 60 °C

3: 53 percent / H₂ / 10percent Pd/C / ethanol; H₂O / Ambient temperature

4: 60 percent / Na / ethanol / 3 h / Heating

5: 1.) POCl₃, N,N-dimethylaniline, 2.) H₂O / 5 h / Heating

With hydrogenchloride; ammonium acetate; water; hydrogen; sodium acetate; sodium; N,N-dimethyl-aniline; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; acetic acid;
DOI:10.1002/hlca.19860690416

Reference yield:

: 94635-19-5
ethyl cyano<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-ylidene>acetate

: 104404-90-2
2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / H₂ / 10percent Pd/C / ethanol; H₂O / Ambient temperature

2: 60 percent / Na / ethanol / 3 h / Heating

3: 1.) POCl₃, N,N-dimethylaniline, 2.) H₂O / 5 h / Heating

With water; hydrogen; sodium; N,N-dimethyl-aniline; trichlorophosphate; palladium on activated charcoal; In ethanol; water;
DOI:10.1002/hlca.19860690416

Reference yield:

: ethyl α-cyano-8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>octane-3-endo-acetate

: 104404-90-2
2,4-diamino-6-chloro-5-<8-(3,5-dimethoxyphenyl)-8-azabicyclo<3.2.1>oct-3-endo-yl>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Na / ethanol / 3 h / Heating

2: 1.) POCl₃, N,N-dimethylaniline, 2.) H₂O / 5 h / Heating

With water; sodium; N,N-dimethyl-aniline; trichlorophosphate; In ethanol;
DOI:10.1002/hlca.19860690416