N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide

Base Information

Chemical Name:N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide
CAS No.:1619983-81-1
Molecular Formula:C₂₂H₃₃NO₅S
Molecular Weight:423.574
Hs Code.:

Synonyms:N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide

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Chemical Property of N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide

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Technology Process of N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide

There total 10 articles about N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₇NO₉S₃

: 1619983-81-1
N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide

Guidance literature:: With water; sodium hydroxide; In methanol; for 72h; Reflux;

Reference yield:

: 1619983-07-1
(1R,2R,4aS,8aS)-1-[(3,5-dimethoxyphenyl)carbonyl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

: 1619983-81-1
N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

2.2: 1.33 h / 0 - 65 °C

3.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 23 h / 20 °C / 760.05 Torr

6.1: boron tribromide / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere

6.2: 0.67 h / 85 °C

7.1: triethylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hydroxide; water / methanol / 72 h / Reflux

With hydrogenchloride; borane-THF; palladium 10% on activated carbon; water; hydrogen; boron tribromide; tin(IV) chloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1619983-08-2
[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](3,5-dimethoxyphenyl)methanone

: 1619983-81-1
N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

1.2: 1.33 h / 0 - 65 °C

2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 23 h / 20 °C / 760.05 Torr

5.1: boron tribromide / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere

5.2: 0.67 h / 85 °C

6.1: triethylamine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

7.1: sodium hydroxide; water / methanol / 72 h / Reflux

With hydrogenchloride; borane-THF; palladium 10% on activated carbon; water; hydrogen; boron tribromide; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;