2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

Base Information

Chemical Name:2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide
CAS No.:1232233-86-1
Molecular Formula:C₂₇H₃₀ClN₇O₂S
Molecular Weight:552.1
Hs Code.:

Synonyms:2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

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Chemical Property of 2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

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Technology Process of 2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

There total 10 articles about 2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232233-85-0
[1-(1-{3-[5-Carbamoyl-4-(3-chloro-phenyl)-thiazol-2-yl]-3H-benzoimidazol-5-ylmethyl}-piperidin-4-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

: 1232233-86-1
2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: [1-(1-{3-[5-Carbamoyl-4-(3-chloro-phenyl)-thiazol-2-yl]-3H-benzoimidazol-5-ylmethyl}-piperidin-4-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 2h;

With sodium hydrogencarbonate;

Reference yield:

: 160538-51-2
3-fluoro-4-nitro-benzaldehyde

: 1232233-86-1
2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / methanol / 1 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3.1: hydrogenchloride; water / acetonitrile / 2 h / 60 °C

4.1: sodium cyanoborohydride / dichloromethane / 3 h

5.1: ammonium chloride; zinc / tetrahydrofuran / 0.42 h

6.1: acetic acid / 1 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h

8.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

8.2: 3 h

9.1: trifluoroacetic acid / dichloromethane / 2 h

With hydrogenchloride; water; sodium cyanoborohydride; ammonium chloride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2-amino-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

: 1232233-86-1
2-{6-[4-(2-amino-2-methyl-propionylamino)-piperidin-1-ylmethyl]-benzoimidazol-1-yl}-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2.1: hydrogenchloride; water / acetonitrile / 2 h / 60 °C

3.1: sodium cyanoborohydride / dichloromethane / 3 h

4.1: ammonium chloride; zinc / tetrahydrofuran / 0.42 h

5.1: acetic acid / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h

7.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

7.2: 3 h

8.1: trifluoroacetic acid / dichloromethane / 2 h

With hydrogenchloride; water; sodium cyanoborohydride; ammonium chloride; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;