Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate

Base Information

Chemical Name:Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate
CAS No.:1352005-44-7
Molecular Formula:C₃₀H₂₆N₄O₃
Molecular Weight:490.561
Hs Code.:

Synonyms:Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate

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Chemical Property of Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate

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Technology Process of Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate

There total 10 articles about Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1352005-43-6
6-(3-bromophenyl)-2-ethyl-4-(quinolin-5-ylamino)pyridazin-3(2H)-one

: 4334-87-6
[3-(ethoxycarbonyl)phenyl]boronic acid

: 1352005-44-7
Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 4964-71-0
5-bromoquinoline

: 1352005-44-7
Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Inert atmosphere

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane;

Reference yield:

: 611-34-7,146614-41-7
5-Aminoquinoline

: 1352005-44-7
Ethyl 3'-(1-ethyl-6-oxo-5-(quinolin-5-ylamino)-1 ,6-dihydropyridazin-3-yl)biphenyl-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogen bromide / water / 0.08 h / 0 - 20 °C

1.2: 2 h / 20 - 75 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Inert atmosphere

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

With hydrogen bromide; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water;