N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide

Base Information

Chemical Name:N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide
CAS No.:1431555-06-4
Molecular Formula:C₃₃H₃₄ClN₅O₆S₂
Molecular Weight:696.248
Hs Code.:

Synonyms:N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide

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Chemical Property of N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide

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Technology Process of N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide

There total 3 articles about N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1312592-31-6
C₂₄H₂₈N₂O₇

: 72836-33-0
2-amino-5-((4-chlorobenzyl)mercapto)-1,3,4-thiadiazole

: 1431555-06-4
N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.cclet.2013.01.052

Reference yield:

: 2826-80-4
N-methyl colchiceinamide

: 1431555-06-4
N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / water / Reflux

2: pyridine / 60 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

With pyridine; dmap; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;
DOI:10.1016/j.cclet.2013.01.052

Reference yield:

: 114099-32-0
N-deacetyl-10-methylamino-10-demethoxycolchicine

: 1431555-06-4
N-deacetyl-N-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}carbamoyl propionyl) N-methyl colchiceinamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 60 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.cclet.2013.01.052