7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426530-74-6
Molecular Formula:C₃₂H₃₄N₈O₂
Molecular Weight:562.674
Hs Code.:

Synonyms:7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of 7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of 7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 5 articles about 7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426530-72-4
7-bromo-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1426530-74-6
7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1134327-98-2
7-bromoimidazo[1,2-a]pyridin-3-carboxylate ethyl ester

: 1426530-74-6
7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / methanol; water / 0.67 h / 60 °C

2.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

2.2: 20 °C / Inert atmosphere

3.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / 100 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; water; caesium carbonate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1019021-93-2
7-bromoimidazol[1,2-a]pyridine-3-carboxylic acid

: 1426530-74-6
7-(1-methyl-1H-pyrazol-5-yl)-N-(2-methyl-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

1.2: 20 °C / Inert atmosphere

2.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / 100 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; caesium carbonate; In N,N-dimethyl-formamide; toluene;