(1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane

Base Information

• Chemical Name: (1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane
• CAS No.: 290295-01-1
• Molecular Formula: C₃₀H₅₀O₈Si₂
• Molecular Weight: 594.893
• Mol file: 290295-01-1.mol

Synonyms:(1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane

Chemical Property of (1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane

There total 1 articles about (1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(E)-1-[3',4',5'-trimethoxyphenyl]-2-[(2'',3''-di[(tert-butyldimethylsilyl)oxy]-4''-methoxy)phenyl]ethene (109984-83-0) → (1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane (290295-01-1)

Guidance literature:

With AD-mix-α; water; In tert-butyl alcohol; at 0 - 20 ℃;

DOI:10.1021/np0000623

Reference yield: 98.0%

acetic anhydride (108-24-7) + (1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane (290295-01-1) → (1S,2S)-1,2-diacetoxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane

Guidance literature:

With pyridine; dmap; In N,N-dimethyl-formamide; for 3h;

DOI:10.1021/np0000623

Reference yield: 68.0%

(1S,2S)-1,2-dihydroxy-1-[2',3'-di(tert-butyldimethylsilyloxy)-4'-methoxyphenyl]-2-(3'',4'',5''-trimethoxyphenyl)ethane (290295-01-1) → (+/-)-2-(2',3'-di[(tert-butyldimethylsilyl)oxy]-4'-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acetaldehyde (309947-17-9)

Guidance literature:

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jo000705j

upstream raw materials:

(E)-1-[3',4',5'-trimethoxyphenyl]-2-[(2'',3''-di[(tert-butyldimethylsilyl)oxy]-4''-methoxy)phenyl]ethene

Downstream raw materials:

(+/-)-2-(2',3'-di[(tert-butyldimethylsilyl)oxy]-4'-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acetaldehyde

(2',3'-dihydroxy-4'-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone