4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

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Chemical Name:4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile
CAS No.:1270977-91-7
Molecular Formula:C₂₅H₂₃F₃N₈O
Molecular Weight:508.506
Hs Code.:

Synonyms:4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

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Chemical Property of 4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

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Technology Process of 4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

There total 7 articles about 4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₇F₃N₈O₂Si

: 76-05-1
trifluoroacetic acid

: 1270977-91-7
4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

Guidance literature:: C₃₁H₃₇F₃N₈O₂Si; With trifluoroacetic acid; In dichloromethane; for 1h;

With ethylenediamine; In methanol; for 1h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 7697-23-6
2-fluoro-4-methylbenzoic Acid

: 1270977-91-7
4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 40 h / Reflux

2.1: silver nitrate / ethanol; water / 0.75 h / 50 °C

2.2: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 2 h

4.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / ethanol / 5 h / 20 °C

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3.5 h

5.2: pH 2

6.1: triethylamine; HATU / tetrahydrofuran / 0.5 h

7.1: trifluoroacetic acid / dichloromethane / 1 h

7.2: 1 h

With N-Bromosuccinimide; lithium hydroxide monohydrate; water; sodium hydride; silver nitrate; triethylamine; HATU; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 604000-97-7
2-fluoro-4-formylbenzoic acid

: 1270977-91-7
4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 2 h

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / ethanol / 5 h / 20 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3.5 h

3.2: pH 2

4.1: triethylamine; HATU / tetrahydrofuran / 0.5 h

5.1: trifluoroacetic acid / dichloromethane / 1 h

5.2: 1 h

With lithium hydroxide monohydrate; water; sodium hydride; triethylamine; HATU; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;