(R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol

Base Information

Chemical Name:(R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol
CAS No.:226950-23-8
Molecular Formula:C₁₉H₃₃NO₃Si
Molecular Weight:351.561
Hs Code.:

Synonyms:(R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol

Chemical Property:

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Technology Process of (R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol

There total 4 articles about (R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 226950-23-8
(R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N / CH₂Cl₂

2: 88.1 percent / pyridinium dichromate / dimethylformamide

3: 86.3 percent / HCO₂H; Et₃N / [Ru(II)(p-cymene)Cl₂]2; (1R,2R)-TsDPEN / 24 h / 28 °C

4: imidazole / dimethylformamide / 35 - 45 °C

With 1H-imidazole; dipyridinium dichromate; formic acid; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b102895m

Reference yield:

: 67341-07-5
tert-butyl N-(2-hydroxy-2-phenylethyl)carbamate

: 226950-23-8
(R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 88.1 percent / pyridinium dichromate / dimethylformamide

2: 86.3 percent / HCO₂H; Et₃N / [Ru(II)(p-cymene)Cl₂]2; (1R,2R)-TsDPEN / 24 h / 28 °C

3: imidazole / dimethylformamide / 35 - 45 °C

With 1H-imidazole; dipyridinium dichromate; formic acid; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In N,N-dimethyl-formamide;
DOI:10.1039/b102895m

Reference yield:

: 76477-26-4
(2-Oxo-2-phenylethyl)carbamic acid tert-butyl ester

: 226950-23-8
(R)-O-(tert-Butyldimethylsilyl)-2-(N-tert-butoxycarbonylamino)-1-phenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 86.3 percent / HCO₂H; Et₃N / [Ru(II)(p-cymene)Cl₂]2; (1R,2R)-TsDPEN / 24 h / 28 °C

2: imidazole / dimethylformamide / 35 - 45 °C

With 1H-imidazole; formic acid; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In N,N-dimethyl-formamide;
DOI:10.1039/b102895m