2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Base Information

Chemical Name:2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one
CAS No.:335278-69-8
Molecular Formula:C₂₅H₂₆FN₃O₂
Molecular Weight:419.499
Hs Code.:

Synonyms:2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

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Chemical Property of 2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

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Technology Process of 2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

There total 6 articles about 2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 528859-67-8
2-tert-butyl-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

: 335278-69-8
2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 110 ℃; for 6h;
DOI:10.1021/jm0205402

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 335278-68-7
5-(3-methoxyphenyl)-6-methyl-2-(tert-butyl)-7H-imidazolo[1,2-a]pyrimid-4-one

: 335278-69-8
2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 335278-69-8
2-tert-butyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / TBAF / 1,2-dichloro-ethane; tetrahydrofuran

2: 61 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene / 6 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene; 2: Suzuki coupling;
DOI:10.1021/jm0205402