8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine

Base Information

Chemical Name:8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine
CAS No.:1268375-78-5
Molecular Formula:C₂₅H₂₁ClN₂OS₂
Molecular Weight:465.04
Hs Code.:

Synonyms:8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine

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Chemical Property of 8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine

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Technology Process of 8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine

There total 8 articles about 8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1268375-59-2
1-(2-(4-chlorobenzoyl)-6-(4-methoxyphenyl)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

: 1268375-78-5
8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine

Guidance literature:: With hydrazine hydrate; In ethanol; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201002506

Reference yield:

: 251-41-2
thieno[3,2-b]thiophene

: 1268375-78-5
8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / 25 °C / Inert atmosphere

2.2: 0.25 h / 25 °C / Inert atmosphere

2.3: 4 h / 25 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / 25 °C / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

3.3: 3 h / -20 - 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 5 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / -50 °C / Inert atmosphere

5.2: 0.25 h / Inert atmosphere

5.3: 2 h / -50 °C / Inert atmosphere

6.1: hydrazine hydrate / ethanol / 12 h / 25 °C / Inert atmosphere

With N-chloro-succinimide; palladium 10% on activated carbon; 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride; ammonium formate; hydrazine hydrate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201002506

Reference yield:

: 1268375-47-8
1-(6-(4-methoxyphenyl)thieno[3,2-b]thiophen-3-yl)-2,2-dimethylpropan-1-one

: 1268375-78-5
8-(tert-butyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)thieno[2',3':4,5]thieno[2,3-d]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride / tetrahydrofuran / -50 °C / Inert atmosphere

1.2: 0.25 h / Inert atmosphere

1.3: 2 h / -50 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 12 h / 25 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinyl magnesium chloride-lithium chloride; hydrazine hydrate; In tetrahydrofuran; ethanol;
DOI:10.1002/chem.201002506