N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

Base Information

Chemical Name:N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide
CAS No.:1065640-81-4
Molecular Formula:C₁₈H₂₄ClN₃O₂S
Molecular Weight:381.926
Hs Code.:

Synonyms:N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

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Chemical Property of N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

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Technology Process of N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

There total 4 articles about N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065640-80-3
(Z)-tert-butyl 2-(5-tert-butyl-2-(5-chloro-2-methoxybenzoylimino)thiazol-3(2H)-yl)ethyl(methyl)carbamate

: 1065640-81-4
N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 2987-16-8
3,3-dimethylbutyrylaldehyde

: 1065640-81-4
N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 24 h / 20 °C / Molecular sieve

1.2: 0.17 h / 50 °C

1.3: 6 h / 50 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With oxalyl dichloride; sodium hydride; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1065640-78-9
tert-butyl 2-(5-tert-butyl-2-iminothiazol-3(2H)-yl)ethylcarbamate

: 1065640-81-4
N-[(2Z)-5-tert-butyl-3-[2-(methylamino)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With oxalyl dichloride; sodium hydride; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; mineral oil;