C₂₅H₂₄N₂O₂

Base Information

• Chemical Name: C₂₅H₂₄N₂O₂
• CAS No.: 1350557-92-4
• Molecular Formula: C₂₅H₂₄N₂O₂
• Molecular Weight: 384.478
• Mol file: 1350557-92-4.mol

Synonyms:C₂₅H₂₄N₂O₂

Chemical Property of C₂₅H₂₄N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₄N₂O₂

There total 5 articles about C₂₅H₂₄N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

indole (120-72-9) + 6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline (1132765-72-0) → C25H24N2O2 (1350557-92-4)

Guidance literature:

With oxygen; vanadia; In water; at 100 ℃; for 24h; under 760.051 Torr; regioselective reaction;

DOI:10.1039/c1cc15050b

Reference yield:

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1745-07-9) → C25H24N2O2 (1350557-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate; ethylene glycol / isopropyl alcohol / 20 - 90 °C / Inert atmosphere

2: oxygen; vanadia / water / 24 h / 100 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; oxygen; vanadia; ethylene glycol; In water; isopropyl alcohol;

DOI:10.1039/c1cc15050b

Reference yield:

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene (4230-93-7) → C25H24N2O2 (1350557-92-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

2.1: formic acid / 0.17 h / 0 °C

2.2: 24 h / 50 °C

3.1: copper(l) iodide; potassium phosphate; ethylene glycol / isopropyl alcohol / 20 - 90 °C / Inert atmosphere

4.1: oxygen; vanadia / water / 24 h / 100 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; formic acid; oxygen; vanadia; ethylene glycol; In tetrahydrofuran; water; isopropyl alcohol;

DOI:10.1039/c1cc15050b

upstream raw materials:

indole

6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene