(±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone

Base Information

Chemical Name:(±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone
CAS No.:1614264-81-1
Molecular Formula:C₁₇H₂₀N₂O₅
Molecular Weight:332.356
Hs Code.:

Synonyms:(±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone

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Technology Process of (±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone

There total 1 articles about (±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2033-24-1
cycl-isopropylidene malonate

: 1694-31-1
tert-butyl acetoacetate

: 99-61-6
3-nitro-benzaldehyde

: 1614264-81-1
(±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone

Guidance literature:: With ammonium acetate; acetic acid; at 80 ℃; for 9h; Reflux;
DOI:10.1016/j.tet.2014.05.012

Reference yield: 81.0%

: 1614264-81-1
(±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone

: 423120-04-1
2-methyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tet.2014.05.012

Reference yield:

: 1614264-81-1
(±)-5-(tert-butoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyridone

: 1614264-53-7,423120-04-1
C₁₃H₁₂N₂O₅

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0 °C

2.1: caesium carbonate / N,N-dimethyl-formamide

2.2: 24 h / 20 °C

3.1: water; Candida antarctica lipase B / tert-butyl methyl ether / 16 h / 28 °C / Enzymatic reaction

With Candida antarctica lipase B; water; caesium carbonate; trifluoroacetic acid; In dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.012