2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

Base Information

Chemical Name:2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide
CAS No.:1383987-36-7
Molecular Formula:C₃₀H₂₇F₂N₅O₆S₂
Molecular Weight:655.703
Hs Code.:

2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

Synonyms:2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

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Chemical Property of 2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

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Technology Process of 2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

There total 6 articles about 2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.5%

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1383991-64-7
6-bromo-2-{[2-(methylsulfonyl)ethyl]amino}-3-(phenylmethyl)-4(3H)-quinazolinone

: 1383987-36-7
2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃;

Reference yield:

: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

: 1383987-36-7
2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2 h / 200 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 6 h / Reflux

3.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 20 °C

3.2: 0 °C / pH 5

4.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

4.2: 0.25 h / 20 °C

4.3: 65 °C

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 130 °C / Inert atmosphere; Sealed tube

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 80 °C

With sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 88145-89-5
6-bromo-1H-quinazoline-2,4-dione

: 1383987-36-7
2,4-difluoro-N-{2-(methyloxy)-5-[2-{[2-(methylsulfonyl)ethyl]amino}-4-oxo-3-(phenylmethyl)-3,4-dihydro-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 6 h / Reflux

2.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 20 °C

2.2: 0 °C / pH 5

3.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

3.2: 0.25 h / 20 °C

3.3: 65 °C

4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 130 °C / Inert atmosphere; Sealed tube

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 80 °C

With sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;