Technology Process of 1,1'-bis(phenylamino)ferrocene
There total 2 articles about 1,1'-bis(phenylamino)ferrocene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis(diphenylphosphino)ferrocene; sodium t-butanolate;
In
tetrahydrofuran; toluene;
(N2); std. Schlenk technique; toluene was added to mixt. of Pd compd. and Fe(C5H4PPh2)2; stirred for 5 min; NaO-t-Bu and C6H5Br were added; after 10 min soln. of Fe(C5H4NH2)2 in THF was added; stirred at 90°C for 70 h; cooled to room temp.; poured into H2O; extd. (Et2O); org. layer dried (Na2SO4); volatiles removed (vac.); extd. (Et2O/hexane, 2/3); filtered through Florisil; concd.; recrystd. (toluene);
DOI:10.1021/om061063e
- Guidance literature:
-
With
potassium hydroxide;
In
ethanol;
all manipulations under Ar or N2; Fe complex and KOH refluxed in EtOH for 16 h; allowed to cool to room temp., extd. with Et2O, dried with Na2SO4, volatiles removed in vac., elem. anal.;
- Guidance literature:
-
With
butyl lithium;
In
hexane;
under Ar; BuLi/hexane added to soln. of 1,1'-bis(phenylamino)ferrocene in hexane at -78°C; stirred for 1 h; allowed to warm to room temp.; stirred for 30 min; cooled to -78°C; soln. of borane in hexane added; stirred at room temp. for 12 h; soln. filtered; filtrate evapd. under vac., oily residue dissolved in toluene; crystn. on cooling at -30°C;
DOI:10.1515/znb-2008-0718
