5-hydroxy-5-phenylpentanenitrile

Base Information

Chemical Name:5-hydroxy-5-phenylpentanenitrile
CAS No.:10413-05-5
Molecular Formula:C₁₁H₁₃NO
Molecular Weight:175.23
Hs Code.:

Synonyms:5-hydroxy-5-phenylpentanenitrile

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Chemical Property of 5-hydroxy-5-phenylpentanenitrile

Chemical Property:

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Technology Process of 5-hydroxy-5-phenylpentanenitrile

There total 8 articles about 5-hydroxy-5-phenylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-50-5,61746-36-9
3-Cyclohexene-1-carboxaldehyde

: 10413-05-5
5-hydroxy-5-phenylpentanenitrile

Guidance literature:: With boron trifluoride diethyl etherate; In tetrahydrofuran; -78 deg C up to -30 deg C within 1 h, stir. 16 h;
DOI:10.1016/S0040-4039(00)80372-X

Reference yield: 74.0%

: 2-phenylcyclopentan-1-one O-(4-(trifluoromethyl)benzoyl)oxime

: 10413-05-5
5-hydroxy-5-phenylpentanenitrile

Guidance literature:: With tris[2-phenylpyridinato-C₂,N]iridium(III); N,N-dimethyl-formamide; In methanol; at 20 ℃; for 2h; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.orglett.7b03707

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 10413-05-5
5-hydroxy-5-phenylpentanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(o-tolyl)phosphine; pyrrolidine; tert-Octylamine; palladium diacetate / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere; Sealed tube; Glovebox

2: hydroxylamine hydrochloride; sodium acetate / methanol / 12 h / 75 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4: tris[2-phenylpyridinato-C₂,N]iridium(III); N,N-dimethyl-formamide / methanol / 2 h / 20 °C / Schlenk technique; Inert atmosphere

With pyrrolidine; tris[2-phenylpyridinato-C₂,N]iridium(III); tert-Octylamine; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; triethylamine; N,N-dimethyl-formamide; tris-(o-tolyl)phosphine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/acs.orglett.7b03707