Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Base Information

Chemical Name:Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester
CAS No.:53273-41-9
Molecular Formula:C₃₂H₂₈O₅
Molecular Weight:492.571
Hs Code.:

Synonyms:Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

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Chemical Property of Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

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Technology Process of Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

There total 5 articles about Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83721-28-2
2-(ethoxycarbonyl)-2-(tert-butoxycarbonyl)indan

: 53273-41-9
Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / p-toluenesulfonic acid hydrate / benzene / 3.5 h / Heating

2: 48 percent / 190 - 200 °C

3: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C, 1.0 h

4: 1.) n-butyllithium / 1.) DME, hexane, 10 min, 2.) DME, hexane, 1.0 h

With n-butyllithium; toluene-4-sulfonic acid; In benzene;
DOI:10.1021/jm00357a004

Reference yield:

: 91-13-4
α,α'-dibromo-o-xylene

: 53273-41-9
Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 30 min, 2.) THF, 1.5 h

2: 100 percent / p-toluenesulfonic acid hydrate / benzene / 3.5 h / Heating

3: 48 percent / 190 - 200 °C

4: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C, 1.0 h

5: 1.) n-butyllithium / 1.) DME, hexane, 10 min, 2.) DME, hexane, 1.0 h

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; In benzene;
DOI:10.1021/jm00357a004

Reference yield:

: 81290-34-8
indan-2-carboxylic acid ethyl ester

: 53273-41-9
Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C, 1.0 h

2: 1.) n-butyllithium / 1.) DME, hexane, 10 min, 2.) DME, hexane, 1.0 h

With n-butyllithium;
DOI:10.1021/jm00357a004