Technology Process of Toluene-4-sulfonic acid (2R,3S,4S,5S)-3,4-dihydroxy-2-hydroxymethyl-5-methoxy-tetrahydro-furan-3-ylmethyl ester
There total 8 articles about Toluene-4-sulfonic acid (2R,3S,4S,5S)-3,4-dihydroxy-2-hydroxymethyl-5-methoxy-tetrahydro-furan-3-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen fluoride;
In
tetrahydrofuran; pyridine;
at 20 ℃;
for 4h;
DOI:10.1021/jo011127p
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 83 percent / phenylmethanol / 3 h / 120 °C
2: 74 percent / pyridine / CH2Cl2 / 4 h / -78 - 0 °C
3: 94 percent / H2 / Pd(OH)2 / methanol / 72 h / 20 °C
4: pyridinium chlorochromate; sodium acetate; molecular sieves 4 Angstroem / CH2Cl2 / 8 h / 20 °C
5: 273 mg / tetrahydrofuran / 13 h / 70 °C
6: RuCl3*H2O; sodium periodate / ethyl acetate; acetonitrile; H2O / 0.5 h / 0 °C
7: 264 mg / 1,4-diazabicyclo[2.2.2]octane / CH2Cl2 / 2 h / 0 °C
8: 85 percent / HF / tetrahydrofuran; pyridine / 4 h / 20 °C
With
pyridine; 1,4-diaza-bicyclo[2.2.2]octane; ruthenium trichloride; sodium periodate; 4 A molecular sieve; hydrogen fluoride; hydrogen; sodium acetate; pyridinium chlorochromate;
palladium dihydroxide;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; water; ethyl acetate; acetonitrile; benzyl alcohol;
DOI:10.1021/jo011127p
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / H2 / Pd(OH)2 / methanol / 72 h / 20 °C
2: pyridinium chlorochromate; sodium acetate; molecular sieves 4 Angstroem / CH2Cl2 / 8 h / 20 °C
3: 273 mg / tetrahydrofuran / 13 h / 70 °C
4: RuCl3*H2O; sodium periodate / ethyl acetate; acetonitrile; H2O / 0.5 h / 0 °C
5: 264 mg / 1,4-diazabicyclo[2.2.2]octane / CH2Cl2 / 2 h / 0 °C
6: 85 percent / HF / tetrahydrofuran; pyridine / 4 h / 20 °C
With
1,4-diaza-bicyclo[2.2.2]octane; ruthenium trichloride; sodium periodate; 4 A molecular sieve; hydrogen fluoride; hydrogen; sodium acetate; pyridinium chlorochromate;
palladium dihydroxide;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo011127p
