(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

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Chemical Name:(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid
CAS No.:178361-88-1
Molecular Formula:C₄₀H₅₀FN₅O₁₂
Molecular Weight:811.862
Hs Code.:

(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

Synonyms:(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

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Chemical Property of (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

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Technology Process of (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

There total 8 articles about (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 178361-88-1
(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

2: EDC,HOBT / dimethylformamide / 0 °C

3: Ph₃P / tetrahydrofuran; H₂O / 23 °C

4: EDC, HOBT / tetrahydrofuran / 0 °C

5: TBAF / dimethylformamide / 0 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00582-5

Reference yield:

: 189007-66-7
(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid 2-trimethylsilanyl-ethyl ester

: 178361-88-1
(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 0 ℃; Yield given;
DOI:10.1016/0040-4039(96)00582-5

Reference yield:

: 28252-50-8
N^α-Cbz-N^γ-(4,4'-dimethoxybenzhydryl)-Asn-OH

: 178361-88-1
(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / DCC, DMAP / dimethylformamide; CH₂Cl₂ / 0 °C

2: 90 percent / H₂ / Pd/C / ethyl acetate; ethanol

3: EDC,HOBT / dimethylformamide / 0 °C

4: Ph₃P / tetrahydrofuran; H₂O / 23 °C

5: EDC, HOBT / tetrahydrofuran / 0 °C

6: TBAF / dimethylformamide / 0 °C

With dmap; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00582-5