(E)-N⁴-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine

Base Information

• Chemical Name: (E)-N⁴-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine
• CAS No.: 148120-93-8
• Molecular Formula: C₄₃H₄₀N₃O₇P
• Molecular Weight: 741.78

Synonyms:(E)-N⁴-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine

Chemical Property of (E)-N⁴-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N⁴-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine

There total 4 articles about (E)-N⁴-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine (148120-90-5) → (E)-N4-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine (148120-93-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 66 percent / methanol / Heating

2: 58 percent / triethylamine / dimethylformamide / 1 h / Ambient temperature

3: 1.) DMSO, dicyclohexylcarbodiimide, dichloroacetic acid, 2.) oxalic acid dihydrate / 1.) RT, 1 h, 2.) DMSO, methanol, RT, 0.5 h

4: dimethylsulfoxide / 18 h / 80 °C

With dichloro-acetic acid; oxalic acid; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00062a006

Reference yield:

1-<(2,2-dimethyl-1,3-dioxan-5yl)methyl>cytosine (148120-88-1) → (E)-N4-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine (148120-93-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / hydrogen chloride / methanol / 1.25 h / Ambient temperature

2: 66 percent / methanol / Heating

3: 58 percent / triethylamine / dimethylformamide / 1 h / Ambient temperature

4: 1.) DMSO, dicyclohexylcarbodiimide, dichloroacetic acid, 2.) oxalic acid dihydrate / 1.) RT, 1 h, 2.) DMSO, methanol, RT, 0.5 h

5: dimethylsulfoxide / 18 h / 80 °C

With hydrogenchloride; dichloro-acetic acid; oxalic acid; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00062a006

Reference yield:

N4-acetyl-1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine (148120-91-6) → (E)-N4-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine (148120-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / triethylamine / dimethylformamide / 1 h / Ambient temperature

2: 1.) DMSO, dicyclohexylcarbodiimide, dichloroacetic acid, 2.) oxalic acid dihydrate / 1.) RT, 1 h, 2.) DMSO, methanol, RT, 0.5 h

3: dimethylsulfoxide / 18 h / 80 °C

With dichloro-acetic acid; oxalic acid; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00062a006

upstream raw materials:

1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine

1-<(2,2-dimethyl-1,3-dioxan-5yl)methyl>cytosine

N⁴-acetyl-1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine

N⁴-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine

Downstream raw materials:

(E)-1-<4-(diphenoxyphosphoryl)-2-(hydroxymethyl)but-3-enyl>cytosine

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