(1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester
CAS No.:740800-47-9
Molecular Formula:C₁₇H₂₄O₂
Molecular Weight:260.376
Hs Code.:

Synonyms:(1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

Suppliers and Price of (1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

There total 4 articles about (1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 740800-46-8
(1R,2R,4S)-1,2-dimethyl-4-methylsulfanylthiocarbonyloxy-2-p-tolyl-cyclopentanecarboxylic acid ethyl ester

: 740800-47-9
(1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 0.666667h; Heating;
DOI:10.1016/j.tet.2004.05.037

Reference yield:

: 740800-45-7
(1R,2R,4S)-4-hydroxy-1,2-dimethyl-2-p-tolyl-cyclopentanecarboxylic acid ethyl ester

: 740800-47-9
(1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 98 percent / tetrahydrofuran / 1 h

2.1: 96 percent / AIBN; Bu₃SnH / toluene / 0.67 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1016/j.tet.2004.05.037

Reference yield:

: 740800-43-5
(1S,2S,4R)-4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-2-p-tolyl-cyclopentanecarboxylic acid ethyl ester

: 740800-47-9
(1R,2R,4S)-1,2-dimethyl-2-p-tolylcyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA; HMPA / tetrahydrofuran; diethyl ether; hexane / 0.67 h / -90 °C

1.2: 93 percent / tetrahydrofuran; diethyl ether; hexane / -90 - 0 °C

2.1: 98 percent / TBAF / tetrahydrofuran / 4 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

3.2: 98 percent / tetrahydrofuran / 1 h

4.1: 96 percent / AIBN; Bu₃SnH / toluene / 0.67 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1016/j.tet.2004.05.037