methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

Base Information

Chemical Name:methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate
CAS No.:187682-45-7
Molecular Formula:C₂₉H₃₂N₂O₉
Molecular Weight:552.581
Hs Code.:

methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

Synonyms:methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

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Chemical Property of methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

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Technology Process of methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

There total 6 articles about methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 187682-44-6
methyl (1aS,8R,8aS,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formylazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate 3-oxide

: 187682-45-7
methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

: methyl (1aR,8R,8aS,8bR)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-2-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

Guidance literature:: With acetic anhydride; In tetrahydrofuran; at 0 ℃; for 40h;
DOI:10.1021/jo961992n

Reference yield:

: 187682-40-2
C₂₆H₂₈N₂O₆

: 187682-45-7
methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃ / CH₂Cl₂; methanol; H₂O / 2 h / Ambient temperature

2: 92 percent / DMAP / pyridine; CH₂Cl₂ / 1 h / Ambient temperature

3: 98 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

4: 59 percent / acetic anhydride / tetrahydrofuran / 40 h / 0 °C

With dmap; acetic anhydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;
DOI:10.1021/jo961992n

Reference yield:

: 187682-39-9
methyl (1aS,8R,8aS,8bR)-1,1a,2,8,8a,8b-hexahydro-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8-(hydroxymethyl)azirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

: 187682-45-7
methyl (1aS,8S,8bS)-1,1a,2,8,8a,8b-hexahydro-8-[(acetyloxy)methyl]-7-(benzyloxy)-1-(tert-butyloxycarbonyl)-8-formyl-8a-hydroxyazirino[2',3':3,4]pyrrolo[1,2-a]indole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / DMAP / pyridine; CH₂Cl₂ / 1 h / Ambient temperature

2: 98 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

3: 59 percent / acetic anhydride / tetrahydrofuran / 40 h / 0 °C

With dmap; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1021/jo961992n