6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

Base Information

Chemical Name:6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile
CAS No.:128667-53-8
Molecular Formula:C₂₁H₂₁N₃O₃
Molecular Weight:363.416
Hs Code.:

Synonyms:6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

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Chemical Property of 6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

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Technology Process of 6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

There total 5 articles about 6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.8%

: 143268-78-4
2-<(cyanoacetyl)amino>-5-<3-(N-methyl-N-benzylamino)-2-hydroxypropoxy>benzaldehyde ethylene acetal

: 128667-53-8
6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00098a003

Reference yield:

: 98454-56-9
5-hydroxy-2-nitrobenzaldehyde ethylene acetal

: 128667-53-8
6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 59.9 percent / K₂CO₃ / methanol / 20 h / Heating

2: H₂ / 5percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

3: Et₃N / ethyl acetate / 0 °C

4: 78.9 percent / methanol / 3 h / Heating

5: 58.8 percent / 2N aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm00098a003

Reference yield:

: 112859-49-1
5-(2,3-epoxypropoxy)-2-nitrobenzaldehyde ethylene acetal

: 128667-53-8
6-[3-(Benzyl-methyl-amino)-2-hydroxy-propoxy]-2-oxo-1,2-dihydro-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

2: Et₃N / ethyl acetate / 0 °C

3: 78.9 percent / methanol / 3 h / Heating

4: 58.8 percent / 2N aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm00098a003