gamma-tert-Butyl aminopterin

Base Information

Chemical Name:gamma-tert-Butyl aminopterin
CAS No.:95484-98-3
Molecular Formula:C23H28 N8 O5
Molecular Weight:496.526
Hs Code.:

Synonyms:gamma-tBAMT;gamma-tert-butyl aminopterin

Suppliers and Price of gamma-tert-Butyl aminopterin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of gamma-tert-Butyl aminopterin

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：208.33000
Density:1.41g/cm³
LogP:3.12750
XLogP3:-0.7
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:11
Exact Mass:496.21826602
Heavy Atom Count:36
Complexity:770

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)C1=CC=C(C=C1)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N
Isomeric SMILES:CC(C)(C)OC(=O)CC[C@@H](C(=O)O)NC(=O)C1=CC=C(C=C1)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N

Technology Process of gamma-tert-Butyl aminopterin

There total 11 articles about gamma-tert-Butyl aminopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 95485-00-0
γ-tert-butyl N-(4-amino-4-deoxy-N¹⁰-formylpteroyl)-L-glutamate

: 95484-98-3
γ-tert-butyl N-(4-amino-4-deoxypteroyl)-L-glutamate

: 54-62-6,64801-55-4
aminopterin

Guidance literature:: With sodium hydroxide; at 25 ℃; for 1.75h;
DOI:10.1021/jm50001a021

Reference yield: 21.0%

: 52853-40-4
6-bromomethyl-2,4-diaminopteridine hydrobromide

: 95485-02-2
γ-tert-butyl N-(p-aminobenzoyl)-L-glutamate

: 95484-98-3
γ-tert-butyl N-(4-amino-4-deoxypteroyl)-L-glutamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 25 ℃; for 22h;
DOI:10.1021/jm50001a021

Reference yield:

: 6234-01-1,16948-36-0
L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride

: 95484-98-3
γ-tert-butyl N-(4-amino-4-deoxypteroyl)-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 18 h

2: 62 percent / aq. NaOH / ethanol / 3.5 h / 25 °C

3: 100 percent / H₂ / PtO₂ / aq. ethanol; acetic acid

4: 21 percent / i-Pr₂NEt / N,N-dimethyl-acetamide / 22 h / 25 °C

With sodium hydroxide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In ethanol; dichloromethane; N,N-dimethyl acetamide; acetic acid;
DOI:10.1021/jm50001a021