(1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate

Base Information

Chemical Name:(1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate
CAS No.:146579-90-0
Molecular Formula:C₁₉H₂₉NO₃
Molecular Weight:319.444
Hs Code.:

Synonyms:(1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate

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Chemical Property of (1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate

Chemical Property:

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Technology Process of (1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate

There total 3 articles about (1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 473545-55-0
(R)-3-((R)-2-Benzyloxy-1-phenyl-ethylamino)-3-cyclohexyl-propionic acid ethyl ester

: 146579-90-0
(1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate

Guidance literature:: With hydrogen; palladium dihydroxide; In acetic acid; under 3040 Torr;
DOI:10.1248/cpb.50.307

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 146579-90-0
(1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate

Guidance literature:: Multi-step reaction with 3 steps

1: molecular sieves 3A / tetrahydrofuran / 4 h / 0 °C

2: RhCl(PPh₃)3; Et₂Zn / tetrahydrofuran; hexane / 0.17 h / 0 °C

3: 40 percent / H₂ / Pd(OH)2 / acetic acid / 3040 Torr

With RhCl(PPh₃)3; 3 A molecular sieve; hydrogen; diethylzinc; palladium dihydroxide; In tetrahydrofuran; hexane; acetic acid; 2: Reformatsky reaction;
DOI:10.1248/cpb.50.307

Reference yield:

: 681-94-7
ethyl 2-(tributylstannyl)acetate

: 104920-44-7,104920-45-8
(2R,4R)-(2S,4R)-2-cyclohexyl-4-phenyl-1,3-oxazolidine

: (S)-3-Cyclohexyl-3-((R)-2-hydroxy-1-phenyl-ethylamino)-propionic acid ethyl ester

: 146579-90-0
(1'R,3R)-ethyl 3-cyclohexyl-3-<(2'-hydroxy-1'-phenyl)ethyl>aminopropionate

Guidance literature:: With boron trifluoride diethyl etherate; zinc(II) chloride; In tetrahydrofuran; diethyl ether; for 72h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;
DOI:10.1016/S0040-4039(00)60054-0