(R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate

Base Information

Chemical Name:(R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate
CAS No.:1332569-84-2
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:(R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate

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Technology Process of (R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate

There total 2 articles about (R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35042-52-5
(E)-2-penten-4-yn-1-ol

: 1332569-84-2
(R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate / dichloromethane / 0.5 h / -10 °C / Inert atmosphere; Molecular sieve

1.2: 24 h / -5 °C / Inert atmosphere; Molecular sieve

2.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 24 h / 40 °C / Inert atmosphere

3.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

With piperidine; titanium(IV) isopropylate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethyl (2S,3S)-tartrate; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Sharpless epoxidation / 1.2: Sharpless epoxidation / 3.1: Sonogashira coupling;
DOI:10.1021/ol202064j

Reference yield:

: 89426-28-8
(2R,3R)-2,3-epoxypent-4-yn-1-ol

: 1332569-84-2
(R)-3-(4-tert-butylphenyl)-1-((S)-2-oxooxazolidin-4-yl)prop-2-ynyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 24 h / 40 °C / Inert atmosphere

2.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

With piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; dichloromethane; 2.1: Sonogashira coupling;
DOI:10.1021/ol202064j