(E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide

Base Information

Chemical Name:(E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide
CAS No.:1374856-11-7
Molecular Formula:C₂₉H₃₀F₃N₅O₃
Molecular Weight:553.584
Hs Code.:

Synonyms:(E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide

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Technology Process of (E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide

There total 6 articles about (E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374856-36-6
C₁₁H₉F₃O₃

: 1374856-71-9
C₁₉H₂₅N₅O

: 1374856-11-7
(E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

: 69559-56-4
N-(2-acetylphenyl)-2,2,2-trichloroacetamide

: 1374856-11-7
(E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium acetate / dimethyl sulfoxide / 24 h / 20 - 35 °C

2: sulfuric acid; silver nitrate / 2.5 h / 0 °C

3: trichlorophosphate / 2 h / 0 °C / Reflux

4: triethylamine / methanol / 2 h / Reflux

5: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 0 - 20 °C

With sulfuric acid; palladium 10% on activated carbon; ammonium acetate; hydrogen; benzotriazol-1-ol; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In methanol; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

: 850172-44-0
2-chloro-4-methyl-6-nitroquinazoline

: 1374856-11-7
(E)-N-(4-methyl-2-(4-(2-oxopyrrolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)but-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 2 h / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.03.049