(3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid

Base Information

Chemical Name:(3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid
CAS No.:159276-74-1
Molecular Formula:C₂₀H₃₂O₅Si
Molecular Weight:380.557
Hs Code.:

Synonyms:(3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid

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Chemical Property of (3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid

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Technology Process of (3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid

There total 5 articles about (3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159276-72-9
(4S,5S)-4-(Dimethyl-p-tolyl-silanyl)-5-[(1S,2S)-1-(dimethyl-p-tolyl-silanyl)-2-hydroxy-3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-dihydro-furan-2-one

: 159276-74-1
(3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: KH / tetrahydrofuran / 1.) -78 to -20 deg C, 2 h; -5 deg C, 1 h, 2.) 0 deg C, 1 h

2: H₂ / PtO₂ / methanol / 50 h / Ambient temperature

With hydrogen; potassium hydride; platinum(IV) oxide; In tetrahydrofuran; methanol;

Reference yield:

: 159276-73-0
(E)-(3S,6S)-3-(Dimethyl-p-tolyl-silanyl)-6-(dimethyl-p-tolyl-silanyloxy)-7-(2-methyl-[1,3]dioxolan-2-yl)-hept-4-enoic acid

: 159276-74-1
(3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; for 50h; Yield given; Ambient temperature;
DOI:10.1039/c39940002285

Reference yield:

: (E)-3,4-Bis-(dimethyl-p-tolyl-silanyl)-7-(2-methyl-[1,3]dioxolan-2-yl)-hept-5-enoic acid

: 159276-74-1
(3R,6R)-3-(Dimethyl-p-tolyl-silanyl)-6-hydroxy-7-(2-methyl-[1,3]dioxolan-2-yl)-heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / MCPBA, Na₂HPO₄ / CH₂Cl₂ / 1.) 0 deg C, 4 h, 2.) r.t., 8 h

2: KH / tetrahydrofuran / 1.) -78 to -20 deg C, 2 h; -5 deg C, 1 h, 2.) 0 deg C, 1 h

3: H₂ / PtO₂ / methanol / 50 h / Ambient temperature

With disodium hydrogenphosphate; hydrogen; potassium hydride; 3-chloro-benzenecarboperoxoic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane;