N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

Base Information

Chemical Name:N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide
CAS No.:1472103-94-8
Molecular Formula:C₂₃H₂₇ClFN₃O₂
Molecular Weight:431.938
Hs Code.:

Synonyms:N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

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Chemical Property of N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

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Technology Process of N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

There total 8 articles about N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1472104-48-5
2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

: 622-95-7
4-chlorobenzyl bromide

: 1472103-94-8
N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; water; benzene; at 23 - 80 ℃; for 0.75h;

Reference yield:

: 1472104-47-4
2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzonitrile

: 1472103-94-8
N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 1 h / 100 °C

2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / benzene; tetrahydrofuran; water / 0.75 h / 23 - 80 °C

With sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In tetrahydrofuran; water; benzene;

Reference yield:

: 1472104-44-1
2-methoxy-6-methyl-4-morpholin-4-yl-benzonitrile

: 1472103-94-8
N-[(4-chlorophenyl)-methyl]-2-[(3R)-3-fluoro-pyrrolidin-1-yl]-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; ethanethiol / N,N-dimethyl-formamide / 16 h / 90 °C

2: caesium carbonate / dichloromethane; acetonitrile / 1 h / 23 °C

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 16.5 h / 90 °C / Inert atmosphere

4: sulfuric acid / 1 h / 100 °C

5: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / benzene; tetrahydrofuran; water / 0.75 h / 23 - 80 °C

With sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ethanethiol; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;