N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine

Base Information

Chemical Name:N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine
CAS No.:1454890-91-5
Molecular Formula:C₂₀H₁₅BrClN₅
Molecular Weight:440.73
Hs Code.:

N<SUP>6</SUP>-((6-bromopyridin-2-yl)methyl)-N<SUP>4</SUP>-(3-chlorophenyl)quinazoline-4,6-diamine

Synonyms:N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine

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Chemical Property of N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine

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Technology Process of N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine

There total 4 articles about N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 153436-71-6
6-amino-4-[(3-chlorophenyl)amino]quinazoline

: 1454890-91-5
N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.06.070

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1454890-91-5
N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: 2 h / Reflux

2: acetic acid / Reflux

3: iron; acetic acid / ethanol / 70 - 80 °C

4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; iron; acetic acid; In ethanol; acetic acid; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2013.06.070

Reference yield:

: 153436-72-7
4-<(3-chlorophenyl)amino>-6-nitroquinazoline

: 1454890-91-5
N⁶-((6-bromopyridin-2-yl)methyl)-N⁴-(3-chlorophenyl)quinazoline-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: iron; acetic acid / ethanol / 70 - 80 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; iron; acetic acid; In ethanol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2013.06.070