2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine

Base Information

Chemical Name:2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine
CAS No.:1360552-04-0
Molecular Formula:C₁₆H₁₉N₅O
Molecular Weight:297.36
Hs Code.:

Synonyms:2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine

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Chemical Property of 2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine

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Technology Process of 2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine

There total 4 articles about 2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1360551-99-0
2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropylpropionitrile

: 1360552-04-0
2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine

Guidance literature:: With hydroxylamine; In ethanol; water; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm501185j

Reference yield:

: C₁₁H₁₀BrN

: 1360552-04-0
2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

1.2: methyl halide / 16 h / Inert atmosphere; Heating

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide / 0.33 h / 90 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3.1: hydroxylamine / ethanol; water / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine; sodium hydride; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm501185j

Reference yield:

: 1360551-88-7
2-(4-bromo-phenyl)-2-cyclopropylpropionitrile

: 1360552-04-0
2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropyl-N-hydroxypropionamidine

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide / 0.33 h / 90 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2: hydroxylamine / ethanol; water / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm501185j