3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one

Base Information

• Chemical Name: 3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one
• CAS No.: 1315058-66-2
• Molecular Formula: C₂₄H₂₄FN₅O
• Molecular Weight: 417.486
• Mol file: 1315058-66-2.mol

Synonyms:3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one

Chemical Property of 3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one

There total 2 articles about 3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-(3-chloropropyl)pyrimido[5,4-c]quinolin-4(3H)-one (1314876-80-6) + 1-(4-Fluorophenyl)piperazine (2252-63-3) → 3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one (1315058-66-2)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 24h; Reflux;

DOI:10.1016/j.ejmech.2011.04.060

Reference yield:

Pyrimido<5,4-c>quinol-1-one (91255-29-7) → 3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one (1315058-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride on basic alumina; potassium iodide / tert-butyl alcohol / 75 °C

2: potassium carbonate; potassium iodide / acetonitrile / 24 h / Reflux

With potassium fluoride on basic alumina; potassium carbonate; potassium iodide; In acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2011.04.060

Reference yield:

3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one (1315058-66-2) → 3-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}pyrimido[5,4-c]quinolin-4(3H)-one dihydrochloride

Guidance literature:

With hydrogenchloride; In diethyl ether; chloroform;

DOI:10.1016/j.ejmech.2011.04.060

upstream raw materials:

3-(3-chloropropyl)pyrimido[5,4-c]quinolin-4(3H)-one

1-(4-Fluorophenyl)piperazine

Pyrimido<5,4-c>quinol-1-one