4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline

Base Information

Chemical Name:4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline
CAS No.:612501-71-0
Molecular Formula:C₂₆H₂₈ClFN₄O₆
Molecular Weight:546.983
Hs Code.:

Synonyms:4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline

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Chemical Property of 4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline

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Technology Process of 4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline

There total 1 articles about 4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 612501-52-7
4-(3-chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinazoline

: 1361054-84-3
1-tert-butyl 2-methyl (2S,4S)-4-(4-nitrobenzenesulfonyloxy)pyrrolidine-1,2-dicarboxylate

: 612501-71-0
4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline

Guidance literature:: With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 612501-71-0
4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline

: 4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-carboxypyrrolidin-4-yloxy]-7-methoxyquinazoline

Guidance literature:: 4-(3-chloro-2-fluoroanilino)-6-[(2S,4R)-1-(t-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidin-4-yloxy]-7-methoxyquinazoline; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; water; pH=6;