(Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate

Base Information

Chemical Name:(Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate
CAS No.:1138342-25-2
Molecular Formula:C₂₂H₂₇NO₃S
Molecular Weight:385.527
Hs Code.:

Synonyms:(Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate

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Chemical Property of (Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate

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Technology Process of (Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate

There total 1 articles about (Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 196929-85-8
(R)-N-benzylidene-2-methylpropane-2-sulfinamide

: 2216-94-6
phenylpropynoic acid ethyl ester

: (Z)-ethyl (R(S),2R)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate

: 1138342-25-2
(Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate

Guidance literature:: phenylpropynoic acid ethyl ester; With diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

(R)-N-benzylidene-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at 70 ℃; for 15h; Inert atmosphere;

With rochelle salt; In tetrahydrofuran; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo9001504

Reference yield: 79.0%

: 1138342-25-2
(Z)-ethyl (R(S),2S)-(-)-2-[phenyl-(2-methylpropane-2-sulfinylamino)methyl]-3-phenylacrylate

: 1138342-31-0
(R(S),2S,3R)-(-)-ethyl 2-benzyl-3-(1,1-dimethylethylsulfinamido)-3-phenylpropanoate

Guidance literature:: With [(bicyclo[2.2.1]hepta-2,5-diene)(1,4-bis(diphenylphosphino)butane)rhodium(I)] tetrafluoroborate; hydrogen; In 1,2-dichloro-ethane; at 20 ℃; for 72h; under 19001.3 Torr; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/jo9001504