C₃₆H₅₀N₂O₄SSi

Base Information

• Chemical Name: C₃₆H₅₀N₂O₄SSi
• CAS No.: 1188304-39-3
• Molecular Formula: C₃₆H₅₀N₂O₄SSi
• Molecular Weight: 634.956
• Mol file: 1188304-39-3.mol

Synonyms:C₃₆H₅₀N₂O₄SSi

Chemical Property of C₃₆H₅₀N₂O₄SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₅₀N₂O₄SSi

There total 11 articles about C₃₆H₅₀N₂O₄SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(2R,7S)-2-((tert-butyldiphenylsilyloxy)methyl)-7-hexyloxepan-3-one (1188304-25-7) + toluene-4-sulfonic acid hydrazide (1576-35-8) → C36H50N2O4SSi (1188304-40-6) + C36H50N2O4SSi (1188304-39-3)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 70 ℃; for 33h; Molecular sieve;

DOI:10.1016/j.tetlet.2009.07.041

Reference yield:

(4aR,6S,8aS)-2,2-di-tert-butyl-6-(hex-2'-enyl)-4,4a,6,8a-tetrahydropyrano[3,2-d][1,3,2]dioxasiline (1188304-31-5) → C36H50N2O4SSi (1188304-39-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C

3.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 18 h / 20 °C / Molecular sieve

5.1: boron trifluoride diethyl etherate / hexane; dichloromethane / 0.5 h / -78 °C

5.2: 1 h / 20 °C

6.1: toluene-4-sulfonic acid / methanol / 33 h / 70 °C / Molecular sieve

With 1H-imidazole; dmap; tetrapropylammonium perruthennate; palladium 10% on activated carbon; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2012.08.094

Reference yield:

(4aR,6S,8aS)-2,2-di-tert-butyl-6-hexylhexahydropyrano[3,2-d][1,3,2]dioxasiline (1188304-32-6) → C36H50N2O4SSi (1188304-39-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 20 °C

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 18 h / 20 °C / Molecular sieve

4.1: boron trifluoride diethyl etherate / hexane; dichloromethane / 0.5 h / -78 °C

4.2: 1 h / 20 °C

5.1: toluene-4-sulfonic acid / methanol / 33 h / 70 °C / Molecular sieve

With 1H-imidazole; dmap; tetrapropylammonium perruthennate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2012.08.094

upstream raw materials:

(2R,7S)-2-((tert-butyldiphenylsilyloxy)methyl)-7-hexyloxepan-3-one

toluene-4-sulfonic acid hydrazide

C₁₂H₂₄O₃

2-{(4aR,6S,8aS)-2,2-di-tert-butyl-4,4a,6,8a-tetrahydropyrano[3,2-d][1,3,2]dioxasilin-6-yl}acetaldehyde

Downstream raw materials:

tert-butyl(((2S,7S)-7-hexyloxepan-2-yl)methoxy)diphenylsilane